Pulsed electromagnetic fields stimulation prevents steroid-induced osteonecrosis in rats

Pulsed electromagnetic fields stimulation prevents steroid-induced osteonecrosis in rats

BACKGROUND Pulsed electromagnetic fields (PEMF) stimulation has been used successfully to treat nonunion fractures and femoral head osteonecrosis, but relatively little is known about its effects on preventing steroid-induced osteonecrosis. The purpose of the study was to investigate the effects of PEMF stimulation on the prevention of steroid-induced osteonecrosis in rats and explore the under...

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Tetramethylpyrazine Enhances Vascularization and Prevents Osteonecrosis in Steroid-Treated Rats

Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is an avascular necrosis disease of bone. Tetramethylpyrazine (TMP), with significant vascular protective properties, has been widely used for the treatments of ischemic neural disorders and cardiovascular diseases. However, its role in the treatment of steroid-induced ONFH has not been evaluated. In this study, our result...

Femoral Perfusion after Electromagnetic Field Stimulation in a Steroid-Induced Osteonecrosis Model

Osteonecrosis Model Akira Ikegami, Keiichiro Ueshima, Kazuya Ikoma, Mikihiro Fujioka, Masazumi Saito, Shigeki Hayashi, Masashi Ishida, Masaaki Kuribayashi, Osam Mazda, Toshikazu Kubo. Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of...

Vitamin E prevents steroid-induced osteonecrosis in rabbits.

BACKGROUND AND PURPOSE Prevention of osteonecrosis after corticosteroid administration would be important. We examined the potential of vitamin E (alpha-tocopherol) to reduce the incidence of corticosteroid-induced osteonecrosis in an animal model. METHODS Japanese white rabbits were divided into 2 groups; the control group was fed a normal diet and the experimental group was fed alpha-tocoph...